Molecular evolution of the CMT1A-REP region: a human- and chimpanzee- specific repeat
نویسندگان
چکیده
منابع مشابه
Primate origin of the CMT1A-REP repeat and analysis of a putative transposon-associated recombinational hotspot.
The CMT1A-REP repeat on chromosome 17p11.2-12 is proposed to mediate misalignment and meiotic unequal crossover leading to a 1.5 Mb pair duplication associated with Charcot-Marie-Tooth neuropathy type 1A (CMT1A) and a reciprocal deletion associated with hereditary neuropathy with liability to pressure palsies (HNPP). Restriction enzyme endonuclease mapping indicated that the size of the CMT1A-R...
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چکیده ندارد.
Effects of chromosomal rearrangements on human-chimpanzee molecular evolution.
Many chromosomes are rearranged between humans and chimpanzees while others remain colinear. It was recently observed, based on over 100 genes, that the rates of protein evolution are substantially higher on rearranged than on colinear chromosomes during human-chimpanzee evolution. This finding led to the conclusion, since debated in the literature, that chromosomal rearrangements had played a ...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 1999
ISSN: 0737-4038,1537-1719
DOI: 10.1093/oxfordjournals.molbev.a026191